Interactions médicamenteuses
Cyclophosphamide + Pentostatin
Gravité: Majeure
Cyclophosphamide and Pentostatin: major interaction.
Dernière mise à jour
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Résumé
Pentostatin combined with high-dose cyclophosphamide in transplant conditioning regimens has been associated with fatal pulmonary edema and hypotension. The combination also increases overall toxicity of both agents.
Ce que signifie cette interaction, en termes simples
Cyclophosphamide and Pentostatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclophosphamide belongs to Oncology; Pentostatin belongs to Oncology.
Pourquoi elle survient
Additive cardiopulmonary and cytotoxic toxicity; the precise mechanism is not fully established.
Conduite à tenir
Avoid pentostatin with high-dose cyclophosphamide in ablative transplant regimens. If standard-dose combinations are used, monitor fluid status, blood pressure and respiratory function closely.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Pentostatin
- Carmustine + Pentostatin Contre-indiquée
- Etoposide + Pentostatin Contre-indiquée
- Fludarabine + Pentostatin Contre-indiquée
- Deferiprone + Pentostatin Majeure
- Fingolimod + Pentostatin Majeure
- Nelarabine + Pentostatin Majeure
Autres interactions de Cyclophosphamide
Questions fréquentes
Can I take Cyclophosphamide with Pentostatin?
MediHelp rates the interaction as major. Cyclophosphamide and Pentostatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pentostatin combined with high-dose cyclophosphamide in transplant conditioning regimens has been associated with fatal pulmonary edema and hypotension. The combination also increases overall toxicity of both agents.
How serious is the interaction between Cyclophosphamide and Pentostatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pentostatin with high-dose cyclophosphamide in ablative transplant regimens. If standard-dose combinations are used, monitor fluid status, blood pressure and respiratory function closely.
What other medicines interact with Pentostatin?
MediHelp also lists interactions of Pentostatin with, for example, Carmustine, Etoposide, Fludarabine. The full list is on the Pentostatin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
