Interactions médicamenteuses
Etoposide + Pentostatin
Gravité: Contre-indiquée
Etoposide and Pentostatin: contraindicated interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
In high-dose transplant conditioning with carmustine and cyclophosphamide, pentostatin was linked to fatal pulmonary edema and hypotension. Use together in this setting is dangerous.
Ce que signifie cette interaction, en termes simples
Etoposide and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Etoposide belongs to Oncology; Pentostatin belongs to Oncology.
Pourquoi elle survient
Mechanism not established; additive pulmonary and cardiovascular toxicity is suspected.
Conduite à tenir
Avoid pentostatin with high-dose etoposide-containing ablative regimens and choose a different conditioning approach.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Etoposide et Pentostatin, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Pentostatin
- Carmustine + Pentostatin Contre-indiquée
- Fludarabine + Pentostatin Contre-indiquée
- Cyclophosphamide + Pentostatin Majeure
- Deferiprone + Pentostatin Majeure
- Fingolimod + Pentostatin Majeure
- Nelarabine + Pentostatin Majeure
Autres interactions de Etoposide
- Adenovirus types 4 and 7 live + Etoposide Contre-indiquée
- Cyclosporine + Etoposide Majeure
- Cyclosporin + Etoposide Majeure
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Etoposide Majeure
- Etoposide + Fingolimod Majeure
- Etoposide + Fosphenytoin Majeure
Questions fréquentes
Can I take Etoposide with Pentostatin?
MediHelp rates the interaction as contraindicated. Etoposide and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. In high-dose transplant conditioning with carmustine and cyclophosphamide, pentostatin was linked to fatal pulmonary edema and hypotension. Use together in this setting is dangerous.
How serious is the interaction between Etoposide and Pentostatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pentostatin with high-dose etoposide-containing ablative regimens and choose a different conditioning approach.
What other medicines interact with Pentostatin?
MediHelp also lists interactions of Pentostatin with, for example, Carmustine, Fludarabine, Cyclophosphamide. The full list is on the Pentostatin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
