Interactions médicamenteuses
Carmustine + Pentostatin
Gravité: Contre-indiquée
Carmustine and Pentostatin: contraindicated interaction.
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Résumé
Pentostatin combined with carmustine, etoposide and high-dose cyclophosphamide in transplant conditioning regimens led to fatal pulmonary toxicity with pulmonary edema and hypotension. Pentostatin should not be used in this setting.
Ce que signifie cette interaction, en termes simples
Carmustine and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Carmustine belongs to Oncology; Pentostatin belongs to Oncology.
Pourquoi elle survient
Mechanism not established; additive pulmonary and cardiovascular toxicity is suspected.
Conduite à tenir
Do not combine pentostatin with high-dose carmustine-based conditioning regimens. Use another regimen.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Pentostatin
- Etoposide + Pentostatin Contre-indiquée
- Fludarabine + Pentostatin Contre-indiquée
- Cyclophosphamide + Pentostatin Majeure
- Deferiprone + Pentostatin Majeure
- Fingolimod + Pentostatin Majeure
- Nelarabine + Pentostatin Majeure
Autres interactions de Carmustine
- Carmustine + Chlorambucil Majeure
- Carmustine + Cimetidine Majeure
- Carmustine + Cyclophosphamide Majeure
- Carmustine + Dacarbazine Majeure
- Carmustine + Fingolimod Majeure
- Carmustine + Lomustine Majeure
Questions fréquentes
Can I take Carmustine with Pentostatin?
MediHelp rates the interaction as contraindicated. Carmustine and Pentostatin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pentostatin combined with carmustine, etoposide and high-dose cyclophosphamide in transplant conditioning regimens led to fatal pulmonary toxicity with pulmonary edema and hypotension. Pentostatin should not be used in this setting.
How serious is the interaction between Carmustine and Pentostatin?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine pentostatin with high-dose carmustine-based conditioning regimens. Use another regimen.
What other medicines interact with Pentostatin?
MediHelp also lists interactions of Pentostatin with, for example, Etoposide, Fludarabine, Cyclophosphamide. The full list is on the Pentostatin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
