Référentiel des médicaments
Pentostatin
Pentostatin is a medicine in the class oncology. It is used for hairy cell leukemia.
- Classe médicamenteuse: Oncology
- Indications: hairy cell leukemia
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Oncology
- Formes courantes
- injection
- Dosages courants
- 2 mg/ml
- Interactions connues
- 14 (Contre-indiquée: 3 · Majeure: 6 · Modérée: 4 · Mineure: 1)
- Noms commerciaux
- 1
- Pays et marchés
- 1
Indications
Mécanisme d'action
Pentostatin is a potent transition state inhibitor of adenosine deaminase (ADA). ADA inhibition leads to cytotoxicity, believed to be due to elevated intracellular dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase.
Posologie adulte habituelle (résumé de la notice)
Hairy cell leukemia: 4 mg/m2 intravenously every other week, by bolus injection or diluted and infused over 20 to 30 minutes; higher doses not recommended
Grossesse et allaitement
- Grossesse
- Unsafe Can cause fetal harm; teratogenic in animals; no adequate human studies. Advise women to avoid pregnancy.
- Allaitement
- Unsafe Not known if excreted in milk; advise not to breastfeed during therapy and for 1 week after the last dose.
Effets indésirables signalés
- Nausea and/or vomiting
- Fever
- Rash
- Fatigue
- Leukopenia
- Pruritus
Mises en garde encadrées
- Give under supervision of a physician experienced in cancer chemotherapy. Higher doses than recommended are not advised; doses of 20-50 mg/m2 in divided doses over 5 days caused severe renal, liver, pulmonary and CNS toxicities. With fludarabine phosphate, 4 of 6 patients had severe or fatal pulmonary toxicity; the combination is not recommended.
Contre-indications
- Hypersensitivity to pentostatin (NIPENT).
Précautions particulières
- Myelosuppression, mainly in the first few courses; monitor complete blood counts frequently early in treatment.
- Pre-existing infections have worsened, in some cases fatally; control infection before starting or resuming.
- Rashes, occasionally severe, are common and may worsen with continued treatment.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (14)
- Carmustine + Pentostatin Contraindicated
- Etoposide + Pentostatin Contraindicated
- Fludarabine + Pentostatin Contraindicated
- Cyclophosphamide + Pentostatin Major
- Deferiprone + Pentostatin Major
- Fingolimod + Pentostatin Major
- Nelarabine + Pentostatin Major
- Pentostatin + Siponimod Major
- Pentostatin + Tofacitinib Major
- Allopurinol + Pentostatin Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- How to give it
- Pharmacokinetics
- Patient counselling points
- IV preparation and dilution
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Questions fréquentes
What is Pentostatin used for?
Pentostatin is a medicine in the class oncology. It is used for Hairy cell leukemia.
What side effects have been reported with Pentostatin?
Nausea and/or vomiting, Fever, Rash, Fatigue, Leukopenia, Pruritus. Serious warning: Give under supervision of a physician experienced in cancer chemotherapy.
Can Pentostatin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm; teratogenic in animals; no adequate human studies. Advise women to avoid pregnancy. Breastfeeding: Unsafe. Not known if excreted in milk; advise not to breastfeed during therapy and for 1 week after the last dose.
What does Pentostatin interact with?
MediHelp lists 14 known interactions for Pentostatin. Contraindicated: 3 · Major: 6 · Moderate: 4 · Minor: 1. The most serious include Carmustine, Etoposide, Fludarabine.
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