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Interactions médicamenteuses

Cyclosporin + Rosuvastatin

Gravité: Majeure

Cyclosporin and Rosuvastatin: major interaction.

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Résumé

Cyclosporine greatly increases rosuvastatin exposure and substantially raises the risk of myopathy and rhabdomyolysis. Rosuvastatin labeling contraindicates or strictly limits use with cyclosporine.

Ce que signifie cette interaction, en termes simples

Cyclosporin and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cyclosporin belongs to Miscellaneous; Rosuvastatin belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Cyclosporine inhibits OATP1B1 and other transporters involved in hepatic uptake of rosuvastatin.

Conduite à tenir

Avoid rosuvastatin where possible, or limit to the labeled maximum dose of 5 mg daily. Use another statin with dose limits if appropriate and monitor for muscle symptoms.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclosporin with Rosuvastatin?

MediHelp rates the interaction as major. Cyclosporin and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine greatly increases rosuvastatin exposure and substantially raises the risk of myopathy and rhabdomyolysis. Rosuvastatin labeling contraindicates or strictly limits use with cyclosporine.

How serious is the interaction between Cyclosporin and Rosuvastatin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid rosuvastatin where possible, or limit to the labeled maximum dose of 5 mg daily. Use another statin with dose limits if appropriate and monitor for muscle symptoms.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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