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Interactions médicamenteuses

Cidofovir + Cyclosporin

Gravité: Contre-indiquée

Cidofovir and Cyclosporin: contraindicated interaction.

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Résumé

Cidofovir causes proximal tubular injury and can lead to acute kidney failure. Cyclosporine causes dose-related renal vasoconstriction and nephrotoxicity, so combining them compounds the risk of renal damage.

Ce que signifie cette interaction, en termes simples

Cidofovir and Cyclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cidofovir belongs to Anti Virals; Cyclosporin belongs to Miscellaneous.

Niveau de preuve: High

Pourquoi elle survient

Additive nephrotoxicity (cidofovir proximal tubule uptake via OAT1 plus partner renal toxicity)

Conduite à tenir

Avoid concurrent use or stop the other nephrotoxin at least 7 days before cidofovir where feasible; if unavoidable give probenecid and saline pre-hydration per the cidofovir protocol and monitor creatinine and urine protein before each dose.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cidofovir with Cyclosporin?

MediHelp rates the interaction as contraindicated. Cidofovir and Cyclosporin are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cidofovir causes proximal tubular injury and can lead to acute kidney failure. Cyclosporine causes dose-related renal vasoconstriction and nephrotoxicity, so combining them compounds the risk of renal damage.

How serious is the interaction between Cidofovir and Cyclosporin?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use or stop the other nephrotoxin at least 7 days before cidofovir where feasible; if unavoidable give probenecid and saline pre-hydration per the cidofovir protocol and monitor creatinine and urine protein before each dose.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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