Interactions médicamenteuses
Cyclosporine + Griseofulvin
Gravité: Majeure
Cyclosporine and Griseofulvin: major interaction.
Dernière mise à jour Sources: US FDA label
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Griseofulvin has been associated with reduced cyclosporine concentrations in case reports. Subtherapeutic levels can lead to graft rejection in transplant recipients.
Ce que signifie cette interaction, en termes simples
Cyclosporine and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Induction of CYP3A4 by griseofulvin increases cyclosporine metabolism.
Conduite à tenir
Monitor cyclosporine trough levels closely when starting or stopping griseofulvin and adjust the dose accordingly; consider an alternative antifungal.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Cyclosporine et Griseofulvin, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.
Références
Autres interactions de Griseofulvin
Questions fréquentes
Can I take Cyclosporine with Griseofulvin?
MediHelp rates the interaction as major. Cyclosporine and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin has been associated with reduced cyclosporine concentrations in case reports. Subtherapeutic levels can lead to graft rejection in transplant recipients.
How serious is the interaction between Cyclosporine and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels closely when starting or stopping griseofulvin and adjust the dose accordingly; consider an alternative antifungal.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
