Interactions médicamenteuses
Ethinyl estradiol-drospirenone + Griseofulvin
Gravité: Majeure
Ethinyl estradiol-drospirenone and Griseofulvin: major interaction.
Dernière mise à jour
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Résumé
Griseofulvin has been associated with breakthrough bleeding, menstrual irregularities and reduced reliability of combined oral contraceptives. Contraceptive failure and unintended pregnancy are possible, which is especially important because griseofulvin is potentially teratogenic.
Ce que signifie cette interaction, en termes simples
Ethinyl estradiol-drospirenone and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethinyl estradiol-drospirenone belongs to Endocrine; Griseofulvin belongs to Anti Fungals.
Pourquoi elle survient
Griseofulvin is thought to induce hepatic enzymes (CYP3A4) and increase metabolism of ethinyl estradiol and the progestin, lowering their exposure.
Conduite à tenir
Add a reliable non-hormonal barrier method throughout griseofulvin therapy and for at least one month after stopping. Consider an alternative antifungal where possible.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contre-indiquée
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contre-indiquée
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Ethinyl estradiol-drospirenone + Tranexamic acid Contre-indiquée
- Aminocaproic acid + Ethinyl estradiol-drospirenone Majeure
- Amobarbital + Ethinyl estradiol-drospirenone Majeure
Autres interactions de Griseofulvin
Questions fréquentes
Can I take Ethinyl estradiol-drospirenone with Griseofulvin?
MediHelp rates the interaction as major. Ethinyl estradiol-drospirenone and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin has been associated with breakthrough bleeding, menstrual irregularities and reduced reliability of combined oral contraceptives. Contraceptive failure and unintended pregnancy are possible, which is especially important because griseofulvin is potentially teratogenic.
How serious is the interaction between Ethinyl estradiol-drospirenone and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a reliable non-hormonal barrier method throughout griseofulvin therapy and for at least one month after stopping. Consider an alternative antifungal where possible.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
