Interactions médicamenteuses
Cyclosporin + Griseofulvin
Gravité: Majeure
Cyclosporin and Griseofulvin: major interaction.
Dernière mise à jour
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Résumé
Griseofulvin can lower cyclosporine blood concentrations, and this has been associated with loss of immunosuppression and graft rejection in case reports. The effect may develop over days to weeks and can persist after griseofulvin is stopped.
Ce que signifie cette interaction, en termes simples
Cyclosporin and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Griseofulvin belongs to Anti Fungals.
Pourquoi elle survient
Griseofulvin induces hepatic and intestinal CYP3A4, accelerating cyclosporine metabolism.
Conduite à tenir
Avoid the combination in transplant patients where possible and consider an alternative antifungal such as terbinafine. If it is unavoidable, monitor cyclosporine trough levels frequently and increase the dose as needed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contre-indiquée
- Aliskiren + Cyclosporin Contre-indiquée
- Bcg vaccine live + Cyclosporin Contre-indiquée
- Bosentan + Cyclosporin Contre-indiquée
- Cidofovir + Cyclosporin Contre-indiquée
- Cyclosporin + Dengue vaccine Contre-indiquée
Autres interactions de Griseofulvin
Questions fréquentes
Can I take Cyclosporin with Griseofulvin?
MediHelp rates the interaction as major. Cyclosporin and Griseofulvin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin can lower cyclosporine blood concentrations, and this has been associated with loss of immunosuppression and graft rejection in case reports. The effect may develop over days to weeks and can persist after griseofulvin is stopped.
How serious is the interaction between Cyclosporin and Griseofulvin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in transplant patients where possible and consider an alternative antifungal such as terbinafine. If it is unavoidable, monitor cyclosporine trough levels frequently and increase the dose as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
