Interactions médicamenteuses
Dabigatran etexilate + Defibrotide
Gravité: Contre-indiquée
Dabigatran etexilate and Defibrotide: contraindicated interaction.
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Résumé
Defibrotide has profibrinolytic activity and may enhance the bleeding risk of anticoagulants. Together with dabigatran this can cause serious hemorrhage.
Ce que signifie cette interaction, en termes simples
Dabigatran etexilate and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dabigatran etexilate belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.
Pourquoi elle survient
Additive pharmacodynamic effects on hemostasis from thrombin inhibition and enhanced fibrinolysis.
Conduite à tenir
Avoid concurrent use; hold dabigatran during defibrotide therapy as directed by the specialist team, considering renal function for washout timing.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Dabigatran etexilate
- Dabigatran etexilate + Ketorolac Contre-indiquée
- Dabigatran etexilate + Mifepristone Contre-indiquée
- Abciximab + Dabigatran etexilate Majeure
- Alteplase + Dabigatran etexilate Majeure
- Amiodarone + Dabigatran etexilate Majeure
- Antithrombin alfa + Dabigatran etexilate Majeure
Autres interactions de Defibrotide
- Alteplase + Defibrotide Contre-indiquée
- Apixaban + Defibrotide Contre-indiquée
- Argatroban + Defibrotide Contre-indiquée
- Dalteparin + Defibrotide Contre-indiquée
- Defibrotide + Edoxaban Contre-indiquée
- Defibrotide + Enoxaparin Contre-indiquée
Questions fréquentes
Can I take Dabigatran etexilate with Defibrotide?
MediHelp rates the interaction as contraindicated. Dabigatran etexilate and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic activity and may enhance the bleeding risk of anticoagulants. Together with dabigatran this can cause serious hemorrhage.
How serious is the interaction between Dabigatran etexilate and Defibrotide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; hold dabigatran during defibrotide therapy as directed by the specialist team, considering renal function for washout timing.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Ketorolac, Mifepristone, Abciximab. The full list is on the Dabigatran etexilate page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
