Interactions médicamenteuses
Dengue vaccine + Fludarabine
Gravité: Majeure
Dengue vaccine and Fludarabine: major interaction.
Dernière mise à jour
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Résumé
Dengue vaccine (Dengvaxia) is a live attenuated vaccine. Fludarabine-induced immunosuppression may blunt the immune response to it, and in a severely immunocompromised patient the live virus could cause vaccine-related disease.
Ce que signifie cette interaction, en termes simples
Dengue vaccine and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Fludarabine-induced lymphocyte depletion reduces the immune response to the vaccine and may allow uncontrolled replication of the live vaccine virus.
Conduite à tenir
Do not give live dengue vaccine during fludarabine therapy or while the patient remains significantly immunosuppressed afterward; vaccinate once immune recovery is confirmed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Fludarabine
- Adenovirus types 4 and 7 live + Fludarabine Contre-indiquée
- Fludarabine + Pentostatin Contre-indiquée
- Belatacept + Fludarabine Majeure
- Etrasimod + Fludarabine Majeure
- Fingolimod + Fludarabine Majeure
- Fludarabine + Ofatumumab sc Majeure
Questions fréquentes
Can I take Dengue vaccine with Fludarabine?
MediHelp rates the interaction as major. Dengue vaccine and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dengue vaccine (Dengvaxia) is a live attenuated vaccine. Fludarabine-induced immunosuppression may blunt the immune response to it, and in a severely immunocompromised patient the live virus could cause vaccine-related disease.
How serious is the interaction between Dengue vaccine and Fludarabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live dengue vaccine during fludarabine therapy or while the patient remains significantly immunosuppressed afterward; vaccinate once immune recovery is confirmed.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Adenovirus types 4 and 7 live, Pentostatin, Belatacept. The full list is on the Fludarabine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
