Interactions médicamenteuses
Etrasimod + Fludarabine
Gravité: Majeure
Etrasimod and Fludarabine: major interaction.
Dernière mise à jour
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Résumé
Etrasimod lowers circulating lymphocytes by sequestering them in lymphoid tissue, and fludarabine causes marked lymphopenia. Together they could cause additive immunosuppression and serious infection, and the combination has not been studied.
Ce que signifie cette interaction, en termes simples
Etrasimod and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Etrasimod belongs to Gastrointestinal Tract; Fludarabine belongs to Oncology.
Pourquoi elle survient
Additive lymphocyte reduction: S1P receptor modulation with purine analog cytotoxicity.
Conduite à tenir
Avoid combining them, and allow an adequate interval after stopping etrasimod before starting fludarabine. If unavoidable, monitor lymphocyte counts and for infection.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Fludarabine
- Adenovirus types 4 and 7 live + Fludarabine Contre-indiquée
- Fludarabine + Pentostatin Contre-indiquée
- Belatacept + Fludarabine Majeure
- Dengue vaccine + Fludarabine Majeure
- Fingolimod + Fludarabine Majeure
- Fludarabine + Ofatumumab sc Majeure
Autres interactions de Etrasimod
- Abatacept + Etrasimod Majeure
- Amiodarone + Etrasimod Majeure
- Anagrelide + Etrasimod Majeure
- Anakinra + Etrasimod Majeure
- Anti-thymocyte + Etrasimod Majeure
- Asenapine + Etrasimod Majeure
Questions fréquentes
Can I take Etrasimod with Fludarabine?
MediHelp rates the interaction as major. Etrasimod and Fludarabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etrasimod lowers circulating lymphocytes by sequestering them in lymphoid tissue, and fludarabine causes marked lymphopenia. Together they could cause additive immunosuppression and serious infection, and the combination has not been studied.
How serious is the interaction between Etrasimod and Fludarabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them, and allow an adequate interval after stopping etrasimod before starting fludarabine. If unavoidable, monitor lymphocyte counts and for infection.
What other medicines interact with Fludarabine?
MediHelp also lists interactions of Fludarabine with, for example, Adenovirus types 4 and 7 live, Pentostatin, Belatacept. The full list is on the Fludarabine page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
