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Interactions médicamenteuses

Desipramine + Pentamidine

Gravité: Contre-indiquée

Desipramine and Pentamidine: contraindicated interaction.

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Résumé

Both drugs can prolong the QT interval, and pentamidine has been associated with torsades de pointes. The combination increases the risk of life-threatening arrhythmia.

Ce que signifie cette interaction, en termes simples

Desipramine and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Desipramine belongs to Central Nervous System; Pentamidine belongs to Anti Parasitic.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation.

Conduite à tenir

Avoid the combination. If pentamidine is essential, consider withholding desipramine and monitor ECG and electrolytes.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Desipramine with Pentamidine?

MediHelp rates the interaction as contraindicated. Desipramine and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and pentamidine has been associated with torsades de pointes. The combination increases the risk of life-threatening arrhythmia.

How serious is the interaction between Desipramine and Pentamidine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If pentamidine is essential, consider withholding desipramine and monitor ECG and electrolytes.

What other medicines interact with Desipramine?

MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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