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Interactions médicamenteuses

Nortriptyline + Pentamidine

Gravité: Contre-indiquée

Nortriptyline and Pentamidine: contraindicated interaction.

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Résumé

Both drugs can prolong the QT interval, and pentamidine has been associated with torsades de pointes. The combination increases arrhythmia risk.

Ce que signifie cette interaction, en termes simples

Nortriptyline and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Nortriptyline belongs to Central Nervous System; Pentamidine belongs to Anti Parasitic.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation.

Conduite à tenir

Avoid the combination. If pentamidine is essential, consider withholding nortriptyline and monitor ECG and electrolytes.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Nortriptyline with Pentamidine?

MediHelp rates the interaction as contraindicated. Nortriptyline and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and pentamidine has been associated with torsades de pointes. The combination increases arrhythmia risk.

How serious is the interaction between Nortriptyline and Pentamidine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If pentamidine is essential, consider withholding nortriptyline and monitor ECG and electrolytes.

What other medicines interact with Nortriptyline?

MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.

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