Interactions médicamenteuses
Dichlorphenamide + Mafenide
Gravité: Majeure
Dichlorphenamide and Mafenide: major interaction.
Dernière mise à jour
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Résumé
Both mafenide, applied to burns, and dichlorphenamide inhibit carbonic anhydrase. Mafenide absorbed over large burn areas can cause metabolic acidosis, and adding systemic dichlorphenamide may deepen this and cause hyperventilation.
Ce que signifie cette interaction, en termes simples
Dichlorphenamide and Mafenide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dichlorphenamide belongs to Miscellaneous; Mafenide belongs to Dermatology.
Pourquoi elle survient
Additive carbonic anhydrase inhibition leading to bicarbonate wasting and metabolic acidosis.
Conduite à tenir
Monitor arterial blood gases or serum bicarbonate closely, especially with extensive burns. Consider stopping mafenide or holding dichlorphenamide if significant acidosis occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Dichlorphenamide
Questions fréquentes
Can I take Dichlorphenamide with Mafenide?
MediHelp rates the interaction as major. Dichlorphenamide and Mafenide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both mafenide, applied to burns, and dichlorphenamide inhibit carbonic anhydrase. Mafenide absorbed over large burn areas can cause metabolic acidosis, and adding systemic dichlorphenamide may deepen this and cause hyperventilation.
How serious is the interaction between Dichlorphenamide and Mafenide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor arterial blood gases or serum bicarbonate closely, especially with extensive burns. Consider stopping mafenide or holding dichlorphenamide if significant acidosis occurs.
What other medicines interact with Dichlorphenamide?
MediHelp also lists interactions of Dichlorphenamide with, for example, Acetazolamide, Acetylsalicylic acid, Ammonium chloride. The full list is on the Dichlorphenamide page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
