Interactions médicamenteuses
Hydroxycarbamide + Stavudine
Gravité: Contre-indiquée
Hydroxycarbamide and Stavudine: contraindicated interaction.
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Résumé
Hydroxycarbamide with stavudine has been linked to fatal and nonfatal pancreatitis, hepatotoxicity and severe peripheral neuropathy. Hepatic failure and lactic acidosis are also of concern.
Ce que signifie cette interaction, en termes simples
Hydroxycarbamide and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Hydroxycarbamide belongs to Oncology; Stavudine belongs to Anti Virals.
Pourquoi elle survient
Additive mitochondrial and organ toxicity, with hydroxycarbamide possibly increasing stavudine-related toxicity.
Conduite à tenir
Do not combine; switch to a safer antiretroviral regimen. Monitor liver enzymes, lipase and neuropathy symptoms if exposure has occurred.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contre-indiquée
Autres interactions de Stavudine
- Didanosine + Stavudine Contre-indiquée
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Stavudine Contre-indiquée
- Stavudine + Zidovudine Contre-indiquée
- Atidarsagene autotemcel + Stavudine Majeure
- Betibeglogene autotemcel + Stavudine Majeure
- Elivaldogene autotemcel + Stavudine Majeure
Questions fréquentes
Can I take Hydroxycarbamide with Stavudine?
MediHelp rates the interaction as contraindicated. Hydroxycarbamide and Stavudine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Hydroxycarbamide with stavudine has been linked to fatal and nonfatal pancreatitis, hepatotoxicity and severe peripheral neuropathy. Hepatic failure and lactic acidosis are also of concern.
How serious is the interaction between Hydroxycarbamide and Stavudine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; switch to a safer antiretroviral regimen. Monitor liver enzymes, lipase and neuropathy symptoms if exposure has occurred.
What other medicines interact with Hydroxycarbamide?
MediHelp also lists interactions of Hydroxycarbamide with, for example, Didanosine. The full list is on the Hydroxycarbamide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
