Drug interactions
Dihydroergotamine + Dopamine
Severity: Contraindicated
Dihydroergotamine and Dopamine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause vasoconstriction, and combined use can produce severe peripheral and cerebral vasospasm with marked hypertension. Ischemic complications have been described with ergot alkaloids and pressor agents.
What this interaction means in plain words
Dihydroergotamine and Dopamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Dopamine belongs to Cardiovascular.
Why it happens
Additive alpha-adrenergic and direct vascular smooth muscle vasoconstriction.
What to do
Avoid combining; use a non-ergot therapy for migraine in patients needing dopamine. If it occurs, monitor perfusion and blood pressure closely.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dihydroergotamine and Dopamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
- Desipramine + Dopamine Major
- Dextroamphetamine + Dopamine Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
- Dihydroergotamine + Ergotamine Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Dopamine?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Dopamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents cause vasoconstriction, and combined use can produce severe peripheral and cerebral vasospasm with marked hypertension. Ischemic complications have been described with ergot alkaloids and pressor agents.
How serious is the interaction between Dihydroergotamine and Dopamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use a non-ergot therapy for migraine in patients needing dopamine. If it occurs, monitor perfusion and blood pressure closely.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Selegiline transdermal, Amitriptyline. The full list is on the Dopamine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
