Drug interactions
Dihydroergotamine + Fluconazole
Severity: Contraindicated
Dihydroergotamine and Fluconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluconazole can raise dihydroergotamine concentrations by inhibiting CYP3A4. Higher exposure raises the risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
What this interaction means in plain words
Dihydroergotamine and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated dihydroergotamine metabolism by fluconazole.
What to do
Avoid the combination and choose another migraine therapy, such as a triptan, while fluconazole is being used. Ensure that patients know the early signs of ischemia.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
- Flibanserin + Fluconazole Contraindicated
- Fluconazole + Levoketoconazole Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Fluconazole?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Fluconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fluconazole can raise dihydroergotamine concentrations by inhibiting CYP3A4. Higher exposure raises the risk of ergotism with severe peripheral and cerebral vasospasm and ischemia.
How serious is the interaction between Dihydroergotamine and Fluconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another migraine therapy, such as a triptan, while fluconazole is being used. Ensure that patients know the early signs of ischemia.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dofetilide, Dronedarone. The full list is on the Fluconazole page.
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