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Interactions médicamenteuses

Diltiazem + Lonafarnib

Gravité: Contre-indiquée

Diltiazem and Lonafarnib: contraindicated interaction.

Dernière mise à jour

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Résumé

Lonafarnib is a sensitive CYP3A4 substrate, and diltiazem as a moderate CYP3A4 inhibitor can substantially increase its exposure. This raises the risk of lonafarnib toxicity, including gastrointestinal effects, renal and hepatic toxicity, and QT-related concerns. Labeling advises against use with moderate or strong CYP3A4 inhibitors.

Ce que signifie cette interaction, en termes simples

Diltiazem and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Diltiazem belongs to Cardiovascular; Lonafarnib belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Diltiazem inhibits CYP3A4, reducing the metabolic clearance of lonafarnib.

Conduite à tenir

Avoid the combination and select a non-CYP3A4-inhibiting alternative to diltiazem. If unavoidable, follow labeling dose-reduction guidance and monitor closely for toxicity.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Diltiazem with Lonafarnib?

MediHelp rates the interaction as contraindicated. Diltiazem and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and diltiazem as a moderate CYP3A4 inhibitor can substantially increase its exposure. This raises the risk of lonafarnib toxicity, including gastrointestinal effects, renal and hepatic toxicity, and QT-related concerns. Labeling advises against use with moderate or strong CYP3A4 inhibitors.

How serious is the interaction between Diltiazem and Lonafarnib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select a non-CYP3A4-inhibiting alternative to diltiazem. If unavoidable, follow labeling dose-reduction guidance and monitor closely for toxicity.

What other medicines interact with Diltiazem?

MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.

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