Aller au contenu

Interactions médicamenteuses

Disopyramide + Gliclazide

Gravité: Majeure

Disopyramide and Gliclazide: major interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Disopyramide can cause hypoglycemia, sometimes severe, and may add to the effect of gliclazide. Elderly patients and those with renal impairment are at greater risk.

Ce que signifie cette interaction, en termes simples

Disopyramide and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Disopyramide belongs to Cardiovascular; Gliclazide belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Disopyramide stimulates insulin secretion through effects on pancreatic potassium channels, additive with sulfonylureas.

Conduite à tenir

Monitor blood glucose closely and reduce the gliclazide dose if needed; consider an alternative antiarrhythmic if recurrent hypoglycemia occurs.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Disopyramide et Gliclazide, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.

Questions fréquentes

Can I take Disopyramide with Gliclazide?

MediHelp rates the interaction as major. Disopyramide and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide can cause hypoglycemia, sometimes severe, and may add to the effect of gliclazide. Elderly patients and those with renal impairment are at greater risk.

How serious is the interaction between Disopyramide and Gliclazide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the gliclazide dose if needed; consider an alternative antiarrhythmic if recurrent hypoglycemia occurs.

What other medicines interact with Gliclazide?

MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Fluconazole. The full list is on the Gliclazide page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter