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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Ciprofloxacin + Gliclazide

Gravité: Majeure

Ciprofloxacin and Gliclazide: major interaction.

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Résumé

Fluoroquinolones such as ciprofloxacin can cause both severe hypoglycemia and hyperglycemia, especially in patients taking sulfonylureas. Older patients and those with renal impairment are at greatest risk.

Ce que signifie cette interaction, en termes simples

Ciprofloxacin and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Ciprofloxacin belongs to Anti Bacterial; Gliclazide belongs to Endocrine.

Niveau de preuve: High

Pourquoi elle survient

Fluoroquinolones alter pancreatic beta-cell insulin release, adding to sulfonylurea-induced insulin secretion; CYP2C9 inhibition may also contribute.

Conduite à tenir

Monitor blood glucose closely during the antibiotic course and warn the patient about hypoglycemia symptoms. Stop the fluoroquinolone and treat if significant glucose disturbance occurs.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ciprofloxacin with Gliclazide?

MediHelp rates the interaction as major. Ciprofloxacin and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones such as ciprofloxacin can cause both severe hypoglycemia and hyperglycemia, especially in patients taking sulfonylureas. Older patients and those with renal impairment are at greatest risk.

How serious is the interaction between Ciprofloxacin and Gliclazide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and warn the patient about hypoglycemia symptoms. Stop the fluoroquinolone and treat if significant glucose disturbance occurs.

What other medicines interact with Gliclazide?

MediHelp also lists interactions of Gliclazide with, for example, Clarithromycin, Disopyramide, Fluconazole. The full list is on the Gliclazide page.

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