Interactions médicamenteuses
Gliclazide + Sulfamethoxazole
Gravité: Majeure
Gliclazide and Sulfamethoxazole: major interaction.
Dernière mise à jour
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Résumé
Sulfamethoxazole, usually given as co-trimoxazole, can enhance the glucose-lowering effect of sulfonylureas and has been linked to serious hypoglycemia. Elderly patients and those with kidney disease are particularly vulnerable.
Ce que signifie cette interaction, en termes simples
Gliclazide and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Sulfamethoxazole inhibits CYP2C9, which metabolizes the sulfonylurea, and may displace it from protein binding.
Conduite à tenir
Monitor blood glucose closely, particularly in the first days of therapy, and lower the gliclazide dose if needed; consider an alternative antibiotic in high-risk patients.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Gliclazide
- Ciprofloxacin + Gliclazide Majeure
- Clarithromycin + Gliclazide Majeure
- Disopyramide + Gliclazide Majeure
- Fluconazole + Gliclazide Majeure
- Gliclazide + Mecasermin Majeure
- Gliclazide + Voriconazole Majeure
Questions fréquentes
Can I take Gliclazide with Sulfamethoxazole?
MediHelp rates the interaction as major. Gliclazide and Sulfamethoxazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sulfamethoxazole, usually given as co-trimoxazole, can enhance the glucose-lowering effect of sulfonylureas and has been linked to serious hypoglycemia. Elderly patients and those with kidney disease are particularly vulnerable.
How serious is the interaction between Gliclazide and Sulfamethoxazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely, particularly in the first days of therapy, and lower the gliclazide dose if needed; consider an alternative antibiotic in high-risk patients.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
