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Interactions médicamenteuses

Clarithromycin + Gliclazide

Gravité: Majeure

Clarithromycin and Gliclazide: major interaction.

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Résumé

Clarithromycin has been associated with hypoglycemia in patients taking sulfonylureas, sometimes severe. Elderly patients and those with renal impairment are particularly vulnerable.

Ce que signifie cette interaction, en termes simples

Clarithromycin and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Clarithromycin belongs to Anti Bacterial; Gliclazide belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Clarithromycin may raise sulfonylurea exposure by inhibiting metabolism and may stimulate insulin release; the exact mechanism is incompletely defined.

Conduite à tenir

Monitor blood glucose closely, or choose a non-macrolide antibiotic where possible. Reduce the gliclazide dose if the combination is essential.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Clarithromycin with Gliclazide?

MediHelp rates the interaction as major. Clarithromycin and Gliclazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin has been associated with hypoglycemia in patients taking sulfonylureas, sometimes severe. Elderly patients and those with renal impairment are particularly vulnerable.

How serious is the interaction between Clarithromycin and Gliclazide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely, or choose a non-macrolide antibiotic where possible. Reduce the gliclazide dose if the combination is essential.

What other medicines interact with Gliclazide?

MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Disopyramide, Fluconazole. The full list is on the Gliclazide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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