Interactions médicamenteuses
Dobutamine + Isocarboxazid
Gravité: Majeure
Dobutamine and Isocarboxazid: major interaction.
Dernière mise à jour
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Résumé
Inhibition of MAO slows catecholamine metabolism and enlarges neuronal stores, and dobutamine is a catecholamine inotrope with beta-1 agonist and some alpha activity. The pressor and chronotropic response to dobutamine can therefore be exaggerated, with severe hypertension, headache and arrhythmia.
Ce que signifie cette interaction, en termes simples
Dobutamine and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dobutamine belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.
Pourquoi elle survient
Reduced catecholamine degradation (MAO inhibition) with sympathomimetic stimulation
Conduite à tenir
Avoid where possible; if dobutamine is required in a patient taking isocarboxazid, start at a markedly reduced dose and titrate against continuous blood-pressure and ECG monitoring.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Dobutamine
- Budesonide-formoterol + Dobutamine Majeure
- Dihydroergotamine intranasal + Dobutamine Majeure
- Dihydroergotamine + Dobutamine Majeure
- Dobutamine + Ergotamine Majeure
- Dobutamine + Ether Majeure
- Dobutamine + Linezolid Majeure
Autres interactions de Isocarboxazid
- 5-HTP + Isocarboxazid Contre-indiquée
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amobarbital + Isocarboxazid Contre-indiquée
- Amoxapine + Isocarboxazid Contre-indiquée
- Apraclonidine + Isocarboxazid Contre-indiquée
- Atomoxetine + Isocarboxazid Contre-indiquée
Questions fréquentes
Can I take Dobutamine with Isocarboxazid?
MediHelp rates the interaction as major. Dobutamine and Isocarboxazid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inhibition of MAO slows catecholamine metabolism and enlarges neuronal stores, and dobutamine is a catecholamine inotrope with beta-1 agonist and some alpha activity. The pressor and chronotropic response to dobutamine can therefore be exaggerated, with severe hypertension, headache and arrhythmia.
How serious is the interaction between Dobutamine and Isocarboxazid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if dobutamine is required in a patient taking isocarboxazid, start at a markedly reduced dose and titrate against continuous blood-pressure and ECG monitoring.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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