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Interactions médicamenteuses

Dobutamine + Linezolid

Gravité: Majeure

Dobutamine and Linezolid: major interaction.

Dernière mise à jour

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Résumé

Inhibition of MAO slows catecholamine metabolism and enlarges neuronal stores, and dobutamine is a catecholamine inotrope with beta-1 agonist and some alpha activity. The pressor and chronotropic response to dobutamine can therefore be exaggerated, with severe hypertension, headache and arrhythmia.

Ce que signifie cette interaction, en termes simples

Dobutamine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dobutamine belongs to Cardiovascular; Linezolid belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Reduced catecholamine degradation (MAO inhibition) with sympathomimetic stimulation

Conduite à tenir

Avoid where possible; if dobutamine is required in a patient taking linezolid, start at a markedly reduced dose and titrate against continuous blood-pressure and ECG monitoring.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dobutamine with Linezolid?

MediHelp rates the interaction as major. Dobutamine and Linezolid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inhibition of MAO slows catecholamine metabolism and enlarges neuronal stores, and dobutamine is a catecholamine inotrope with beta-1 agonist and some alpha activity. The pressor and chronotropic response to dobutamine can therefore be exaggerated, with severe hypertension, headache and arrhythmia.

How serious is the interaction between Dobutamine and Linezolid?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if dobutamine is required in a patient taking linezolid, start at a markedly reduced dose and titrate against continuous blood-pressure and ECG monitoring.

What other medicines interact with Linezolid?

MediHelp also lists interactions of Linezolid with, for example, Amoxapine, Atomoxetine, Benzphetamine. The full list is on the Linezolid page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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