Drug interactions
Dolasetron + Thioridazine
Severity: Contraindicated
Dolasetron and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine causes marked, dose-related QT prolongation and is itself associated with torsades de pointes. Adding dolasetron substantially increases the risk of fatal arrhythmia.
What this interaction means in plain words
Dolasetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dolasetron belongs to Gastrointestinal Tract; Thioridazine belongs to Central Nervous System.
Why it happens
Additive potassium channel blockade producing marked QT prolongation.
What to do
Do not combine; choose an antiemetic from a class without QT effects such as a dopamine antagonist alternative with low risk. Thioridazine labeling advises against use with other QT-prolonging agents.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Vandetanib Contraindicated
- Dolasetron + Ziprasidone Contraindicated
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Dolasetron with Thioridazine?
MediHelp rates the interaction as contraindicated. Dolasetron and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine causes marked, dose-related QT prolongation and is itself associated with torsades de pointes. Adding dolasetron substantially increases the risk of fatal arrhythmia.
How serious is the interaction between Dolasetron and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; choose an antiemetic from a class without QT effects such as a dopamine antagonist alternative with low risk. Thioridazine labeling advises against use with other QT-prolonging agents.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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