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Interactions médicamenteuses

Doravirine + Enzalutamide

Gravité: Contre-indiquée

Doravirine and Enzalutamide: contraindicated interaction.

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Résumé

Enzalutamide lowers doravirine concentrations through strong CYP3A induction, and doravirine labeling contraindicates strong CYP3A inducers. Reduced exposure may cause loss of virologic control and resistance.

Ce que signifie cette interaction, en termes simples

Doravirine and Enzalutamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Doravirine belongs to Anti Virals; Enzalutamide belongs to Endocrine.

Niveau de preuve: High

Pourquoi elle survient

Induction of CYP3A4 by enzalutamide increases doravirine metabolism.

Conduite à tenir

Do not coadminister; select a different antiretroviral regimen or antiandrogen. Monitor HIV RNA if the inducer was recently stopped.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Doravirine with Enzalutamide?

MediHelp rates the interaction as contraindicated. Doravirine and Enzalutamide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Enzalutamide lowers doravirine concentrations through strong CYP3A induction, and doravirine labeling contraindicates strong CYP3A inducers. Reduced exposure may cause loss of virologic control and resistance.

How serious is the interaction between Doravirine and Enzalutamide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; select a different antiretroviral regimen or antiandrogen. Monitor HIV RNA if the inducer was recently stopped.

What other medicines interact with Enzalutamide?

MediHelp also lists interactions of Enzalutamide with, for example, Elbasvir / grazoprevir, Ensitrelvir, Fostemsavir. The full list is on the Enzalutamide page.

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