Interactions médicamenteuses
Doxycycline + Magnesium sulphate
Gravité: Modérée
Doxycycline and Magnesium sulphate: moderate interaction.
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Résumé
Oral magnesium salts bind tetracyclines in the gut and reduce their absorption, which can lead to subtherapeutic antibiotic levels and treatment failure. The interaction is relevant only when both are given orally.
Ce que signifie cette interaction, en termes simples
Doxycycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxycycline belongs to Anti Bacterial; Magnesium sulphate belongs to Cardiovascular.
Pourquoi elle survient
Chelation of doxycycline by divalent magnesium cations in the gastrointestinal tract, forming poorly absorbed complexes.
Conduite à tenir
Give doxycycline at least 2 hours before or several hours after oral magnesium. Intravenous magnesium does not need separation.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Magnesium sulphate
Autres interactions de Doxycycline
- Acitretin + Doxycycline Contre-indiquée
- Aminolevulinic acid + Doxycycline Majeure
- Cholera vaccine + Doxycycline Majeure
- Doxycycline + Isotretinoin Majeure
- Doxycycline + Methoxyflurane Majeure
- Doxycycline + Microbiota Majeure
Questions fréquentes
Can I take Doxycycline with Magnesium sulphate?
MediHelp rates the interaction as moderate. Doxycycline and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium salts bind tetracyclines in the gut and reduce their absorption, which can lead to subtherapeutic antibiotic levels and treatment failure. The interaction is relevant only when both are given orally.
How serious is the interaction between Doxycycline and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give doxycycline at least 2 hours before or several hours after oral magnesium. Intravenous magnesium does not need separation.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Atracurium. The full list is on the Magnesium sulphate page.
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