Interactions médicamenteuses
Amikacin + Magnesium sulphate
Gravité: Modérée
Amikacin and Magnesium sulphate: moderate interaction.
Dernière mise à jour
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Résumé
Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia. Magnesium sulfate also potentiates neuromuscular blockade, which aminoglycosides can cause, so combined use may increase the risk of respiratory muscle weakness.
Ce que signifie cette interaction, en termes simples
Amikacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Magnesium sulphate belongs to Cardiovascular.
Pourquoi elle survient
Aminoglycoside tubular toxicity increases renal magnesium loss, and both agents impair neuromuscular transmission, producing additive effects.
Conduite à tenir
Monitor serum magnesium and renal function, and watch for muscle weakness or respiratory depression, especially with parenteral magnesium. Replace magnesium as needed.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Magnesium sulphate
Autres interactions de Amikacin
- Amikacin + Cidofovir Contre-indiquée
- Adefovir + Amikacin Majeure
- Amikacin + Amphotericin b Majeure
- Amikacin + Amphotericin b deoxycholate Majeure
- Amikacin + Atracurium Majeure
- Amikacin + Bacitracin Majeure
Questions fréquentes
Can I take Amikacin with Magnesium sulphate?
MediHelp rates the interaction as moderate. Amikacin and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can cause renal magnesium wasting, leading to hypomagnesemia. Magnesium sulfate also potentiates neuromuscular blockade, which aminoglycosides can cause, so combined use may increase the risk of respiratory muscle weakness.
How serious is the interaction between Amikacin and Magnesium sulphate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium and renal function, and watch for muscle weakness or respiratory depression, especially with parenteral magnesium. Replace magnesium as needed.
What other medicines interact with Magnesium sulphate?
MediHelp also lists interactions of Magnesium sulphate with, for example, Amphotericin b deoxycholate, Atracurium, Baloxavir marboxil. The full list is on the Magnesium sulphate page.
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