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Interactions médicamenteuses

Atracurium + Magnesium sulphate

Gravité: Modérée

Atracurium and Magnesium sulphate: moderate interaction.

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Résumé

Parenteral magnesium sulfate potentiates non-depolarising neuromuscular blockers, producing a deeper and longer block. Recovery may be delayed and respiratory support extended.

Ce que signifie cette interaction, en termes simples

Atracurium and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Atracurium belongs to Musculoskeletal; Magnesium sulphate belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Magnesium reduces presynaptic acetylcholine release and decreases postsynaptic sensitivity at the neuromuscular junction, adding to competitive blockade.

Conduite à tenir

Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Allow for delayed recovery and check serum magnesium.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Atracurium with Magnesium sulphate?

MediHelp rates the interaction as moderate. Atracurium and Magnesium sulphate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parenteral magnesium sulfate potentiates non-depolarising neuromuscular blockers, producing a deeper and longer block. Recovery may be delayed and respiratory support extended.

How serious is the interaction between Atracurium and Magnesium sulphate?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the neuromuscular blocker dose and monitor with quantitative train-of-four. Allow for delayed recovery and check serum magnesium.

What other medicines interact with Magnesium sulphate?

MediHelp also lists interactions of Magnesium sulphate with, for example, Amikacin, Amphotericin b deoxycholate, Baloxavir marboxil. The full list is on the Magnesium sulphate page.

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