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Interactions médicamenteuses

Duloxetine + Isocarboxazid

Gravité: Contre-indiquée

Duloxetine and Isocarboxazid: contraindicated interaction.

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Résumé

Isocarboxazid irreversibly inhibits both MAO-A and MAO-B, so adding duloxetine (a serotonin-noradrenaline reuptake inhibitor) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.

Ce que signifie cette interaction, en termes simples

Duloxetine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Duloxetine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Inhibition of monoamine oxidase combined with a serotonin-noradrenaline reuptake inhibitor activity leading to excess serotonergic stimulation

Conduite à tenir

Do not co-administer. Allow at least 14 days after stopping the MAOI before starting duloxetine, and 5 days after stopping duloxetine before starting an MAOI.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Duloxetine with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Duloxetine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits both MAO-A and MAO-B, so adding duloxetine (a serotonin-noradrenaline reuptake inhibitor) can allow serotonin to accumulate excessively. Serotonin syndrome (hyperthermia, clonus, agitation, autonomic instability) can be severe or fatal.

How serious is the interaction between Duloxetine and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Allow at least 14 days after stopping the MAOI before starting duloxetine, and 5 days after stopping duloxetine before starting an MAOI.

What other medicines interact with Duloxetine?

MediHelp also lists interactions of Duloxetine with, for example, Linezolid, Methylene blue, Phenelzine. The full list is on the Duloxetine page.

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