Aller au contenu
MediHelp
MediHelp Référence médicamenteuse

Interactions médicamenteuses

Duloxetine + Rasagiline

Gravité: Contre-indiquée

Duloxetine and Rasagiline: contraindicated interaction.

Dernière mise à jour

Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.

Le contenu clinique de cette page n'est disponible qu'en anglais.

Résumé

Combining an MAO inhibitor with an SNRI can cause serotonin syndrome and severe CNS toxicity with hyperthermia. Duloxetine labeling contraindicates use with MAO inhibitors, and rasagiline labeling advises against combining with antidepressants.

Ce que signifie cette interaction, en termes simples

Duloxetine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Duloxetine belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

MAO-B inhibition (with reduced selectivity at higher doses) combined with serotonin and norepinephrine reuptake inhibition causes excess synaptic monoamines.

Conduite à tenir

Do not coadminister. Allow at least 14 days after stopping rasagiline before starting duloxetine, and at least 5 days after stopping duloxetine before starting rasagiline.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

Réservé aux membres Pro+

Débloquer la page complète

Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Duloxetine et Rasagiline, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription
Créer un compte gratuit Se connecter

Essayez Pro+ gratuitement pendant 7 jours sur le web. Sans carte.

Questions fréquentes

Can I take Duloxetine with Rasagiline?

MediHelp rates the interaction as contraindicated. Duloxetine and Rasagiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAO inhibitor with an SNRI can cause serotonin syndrome and severe CNS toxicity with hyperthermia. Duloxetine labeling contraindicates use with MAO inhibitors, and rasagiline labeling advises against combining with antidepressants.

How serious is the interaction between Duloxetine and Rasagiline?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister. Allow at least 14 days after stopping rasagiline before starting duloxetine, and at least 5 days after stopping duloxetine before starting rasagiline.

What other medicines interact with Duloxetine?

MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

Télécharger surApp Store Disponible surGoogle Play

Parcourir de A à Z · Interactions médicamenteuses

Télécharger l'app Se connecter