Interactions médicamenteuses
Eluxadoline + Loperamide
Gravité: Majeure
Eluxadoline and Loperamide: major interaction.
Dernière mise à jour
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Résumé
Eluxadoline is a gut-acting opioid agonist and loperamide also slows gut motility, so together they raise the risk of severe constipation. Serious outcomes include ileus and pancreatitis-related complications noted in eluxadoline labeling.
Ce que signifie cette interaction, en termes simples
Eluxadoline and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eluxadoline belongs to Gastrointestinal Tract; Loperamide belongs to Gastrointestinal Tract.
Pourquoi elle survient
Additive opioid receptor-mediated reduction in gastrointestinal motility.
Conduite à tenir
Avoid chronic loperamide use with eluxadoline; occasional use for severe acute diarrhea is acceptable. Stop loperamide immediately if constipation develops.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Loperamide
- Amiodarone + Loperamide Majeure
- Amisulpride + Loperamide Majeure
- Anagrelide + Loperamide Majeure
- Artemether / lumefantrine + Loperamide Majeure
- Artemether + Loperamide Majeure
- Asenapine + Loperamide Majeure
Autres interactions de Eluxadoline
- Alosetron + Eluxadoline Majeure
- Atropine + Eluxadoline Majeure
- Buprenorphine + Eluxadoline Majeure
- Cyclosporin + Eluxadoline Majeure
- Diphenoxylate-atropine + Eluxadoline Majeure
- Eluxadoline + Hydromorphone Majeure
Questions fréquentes
Can I take Eluxadoline with Loperamide?
MediHelp rates the interaction as major. Eluxadoline and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline is a gut-acting opioid agonist and loperamide also slows gut motility, so together they raise the risk of severe constipation. Serious outcomes include ileus and pancreatitis-related complications noted in eluxadoline labeling.
How serious is the interaction between Eluxadoline and Loperamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic loperamide use with eluxadoline; occasional use for severe acute diarrhea is acceptable. Stop loperamide immediately if constipation develops.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
