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Interactions médicamenteuses

Diphenoxylate-atropine + Eluxadoline

Gravité: Majeure

Diphenoxylate-atropine and Eluxadoline: major interaction.

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Résumé

Eluxadoline is an opioid receptor modulator whose labeling warns against use with drugs that cause constipation. Diphenoxylate-atropine is strongly constipating and increases the risk of serious complications such as ileus or obstruction.

Ce que signifie cette interaction, en termes simples

Diphenoxylate-atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Diphenoxylate-atropine belongs to Gastrointestinal Tract; Eluxadoline belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive inhibition of gastrointestinal motility via opioid and anticholinergic effects.

Conduite à tenir

Avoid using the two together. If constipation or abdominal pain develops, stop the agents and assess for ileus.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Diphenoxylate-atropine with Eluxadoline?

MediHelp rates the interaction as major. Diphenoxylate-atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline is an opioid receptor modulator whose labeling warns against use with drugs that cause constipation. Diphenoxylate-atropine is strongly constipating and increases the risk of serious complications such as ileus or obstruction.

How serious is the interaction between Diphenoxylate-atropine and Eluxadoline?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two together. If constipation or abdominal pain develops, stop the agents and assess for ileus.

What other medicines interact with Diphenoxylate-atropine?

MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.

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