Drug interactions
Eluxadoline + Loperamide
Severity: Major
Eluxadoline and Loperamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is a gut-acting opioid agonist and loperamide also slows gut motility, so together they raise the risk of severe constipation. Serious outcomes include ileus and pancreatitis-related complications noted in eluxadoline labeling.
What this interaction means in plain words
Eluxadoline and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eluxadoline belongs to Gastrointestinal Tract; Loperamide belongs to Gastrointestinal Tract.
Why it happens
Additive opioid receptor-mediated reduction in gastrointestinal motility.
What to do
Avoid chronic loperamide use with eluxadoline; occasional use for severe acute diarrhea is acceptable. Stop loperamide immediately if constipation develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Loperamide
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Loperamide?
MediHelp rates the interaction as major. Eluxadoline and Loperamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline is a gut-acting opioid agonist and loperamide also slows gut motility, so together they raise the risk of severe constipation. Serious outcomes include ileus and pancreatitis-related complications noted in eluxadoline labeling.
How serious is the interaction between Eluxadoline and Loperamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic loperamide use with eluxadoline; occasional use for severe acute diarrhea is acceptable. Stop loperamide immediately if constipation develops.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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