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Interactions médicamenteuses

Eluxadoline + Hydromorphone

Gravité: Majeure

Eluxadoline and Hydromorphone: major interaction.

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Résumé

Eluxadoline acts on opioid receptors in the gut and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Hydromorphone also slows gut motility, so combined use raises the risk of severe constipation and related complications.

Ce que signifie cette interaction, en termes simples

Eluxadoline and Hydromorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Eluxadoline belongs to Gastrointestinal Tract; Hydromorphone belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive inhibition of gastrointestinal motility via opioid receptor activity.

Conduite à tenir

Avoid the combination if possible; if used, monitor bowel function closely and stop eluxadoline if severe constipation develops. Use a laxative regimen appropriately for the opioid.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Eluxadoline with Hydromorphone?

MediHelp rates the interaction as major. Eluxadoline and Hydromorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline acts on opioid receptors in the gut and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Hydromorphone also slows gut motility, so combined use raises the risk of severe constipation and related complications.

How serious is the interaction between Eluxadoline and Hydromorphone?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, monitor bowel function closely and stop eluxadoline if severe constipation develops. Use a laxative regimen appropriately for the opioid.

What other medicines interact with Hydromorphone?

MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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