Interactions médicamenteuses
Bosentan + Levonorgestrel
Gravité: Majeure
Bosentan and Levonorgestrel: major interaction.
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Résumé
Bosentan induces CYP3A4 and may lower systemic levonorgestrel exposure from oral or emergency products. The intrauterine system acts mainly locally and is much less affected, so the concern is mainly for systemic formulations, and bosentan is teratogenic.
Ce que signifie cette interaction, en termes simples
Bosentan and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosentan belongs to Miscellaneous; Levonorgestrel belongs to Endocrine.
Pourquoi elle survient
Bosentan induces CYP3A4, increasing the metabolism of levonorgestrel.
Conduite à tenir
Use a reliable method that does not depend on systemic hormone levels, such as an intrauterine system or copper IUD, rather than oral levonorgestrel alone. Consider a higher emergency contraception dose or a copper IUD for emergency use.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Levonorgestrel
- Amobarbital + Levonorgestrel Majeure
- Apalutamide + Levonorgestrel Majeure
- Belzutifan + Levonorgestrel Majeure
- Brigatinib + Levonorgestrel Majeure
- Carbamazepine + Levonorgestrel Majeure
- Cenobamate + Levonorgestrel Majeure
Autres interactions de Bosentan
- Bosentan + Cyclosporin Contre-indiquée
- Bosentan + Cyclosporine Contre-indiquée
- Bosentan + Glyburide Contre-indiquée
- Bosentan + Glyburide-metformin Contre-indiquée
- Bosentan + Lonafarnib Contre-indiquée
- Bosentan + Sparsentan Contre-indiquée
Questions fréquentes
Can I take Bosentan with Levonorgestrel?
MediHelp rates the interaction as major. Bosentan and Levonorgestrel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bosentan induces CYP3A4 and may lower systemic levonorgestrel exposure from oral or emergency products. The intrauterine system acts mainly locally and is much less affected, so the concern is mainly for systemic formulations, and bosentan is teratogenic.
How serious is the interaction between Bosentan and Levonorgestrel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reliable method that does not depend on systemic hormone levels, such as an intrauterine system or copper IUD, rather than oral levonorgestrel alone. Consider a higher emergency contraception dose or a copper IUD for emergency use.
What other medicines interact with Levonorgestrel?
MediHelp also lists interactions of Levonorgestrel with, for example, Amobarbital, Apalutamide, Belzutifan. The full list is on the Levonorgestrel page.
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