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Interactions médicamenteuses

Enzalutamide + Netupitant-palonosetron

Gravité: Majeure

Enzalutamide and Netupitant-palonosetron: major interaction.

Dernière mise à jour

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Résumé

Enzalutamide is a strong CYP3A4 inducer and is expected to substantially lower netupitant concentrations. This may lead to reduced prevention of chemotherapy-induced nausea and vomiting. The effect can persist after enzalutamide is stopped.

Ce que signifie cette interaction, en termes simples

Enzalutamide and Netupitant-palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Enzalutamide belongs to Endocrine; Netupitant-palonosetron belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Strong CYP3A4 induction by enzalutamide increases netupitant metabolism.

Conduite à tenir

Avoid the fixed combination and choose an antiemetic regimen not dependent on CYP3A4 exposure. If used, monitor closely for breakthrough emesis.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Enzalutamide with Netupitant-palonosetron?

MediHelp rates the interaction as major. Enzalutamide and Netupitant-palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Enzalutamide is a strong CYP3A4 inducer and is expected to substantially lower netupitant concentrations. This may lead to reduced prevention of chemotherapy-induced nausea and vomiting. The effect can persist after enzalutamide is stopped.

How serious is the interaction between Enzalutamide and Netupitant-palonosetron?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the fixed combination and choose an antiemetic regimen not dependent on CYP3A4 exposure. If used, monitor closely for breakthrough emesis.

What other medicines interact with Netupitant-palonosetron?

MediHelp also lists interactions of Netupitant-palonosetron with, for example, Apomorphine, Flibanserin, Apalutamide. The full list is on the Netupitant-palonosetron page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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