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Interactions médicamenteuses

Ephedrine + Phenelzine

Gravité: Contre-indiquée

Ephedrine and Phenelzine: contraindicated interaction.

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Résumé

Ephedrine releases norepinephrine, and MAO inhibitors greatly enhance this effect. Hypertensive crisis with severe headache and possible stroke can occur.

Ce que signifie cette interaction, en termes simples

Ephedrine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ephedrine belongs to Cardiovascular; Phenelzine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

MAO inhibition prevents norepinephrine breakdown, amplifying the indirect sympathomimetic action of ephedrine.

Conduite à tenir

Avoid ephedrine and ephedrine-containing products during phenelzine therapy and for 14 days after. If a pressor is needed in emergencies, use a direct-acting agent at reduced dose with close monitoring.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ephedrine with Phenelzine?

MediHelp rates the interaction as contraindicated. Ephedrine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine releases norepinephrine, and MAO inhibitors greatly enhance this effect. Hypertensive crisis with severe headache and possible stroke can occur.

How serious is the interaction between Ephedrine and Phenelzine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine and ephedrine-containing products during phenelzine therapy and for 14 days after. If a pressor is needed in emergencies, use a direct-acting agent at reduced dose with close monitoring.

What other medicines interact with Phenelzine?

MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.

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