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Interactions médicamenteuses

Ephedrine + Isocarboxazid

Gravité: Contre-indiquée

Ephedrine and Isocarboxazid: contraindicated interaction.

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Résumé

Ephedrine with an MAOI can cause severe hypertension and hypertensive crisis. Effects can be markedly greater than expected.

Ce que signifie cette interaction, en termes simples

Ephedrine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ephedrine belongs to Cardiovascular; Isocarboxazid belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Ephedrine releases norepinephrine from nerve terminals that are loaded because of MAO inhibition, and metabolism is reduced, producing exaggerated pressor effects.

Conduite à tenir

Avoid ephedrine, including in cold remedies, during and for 14 days after MAOI therapy. If a vasopressor is needed perioperatively, use a direct-acting agent in carefully titrated small doses with close monitoring.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ephedrine with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Ephedrine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine with an MAOI can cause severe hypertension and hypertensive crisis. Effects can be markedly greater than expected.

How serious is the interaction between Ephedrine and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine, including in cold remedies, during and for 14 days after MAOI therapy. If a vasopressor is needed perioperatively, use a direct-acting agent in carefully titrated small doses with close monitoring.

What other medicines interact with Isocarboxazid?

MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.

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