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Interactions médicamenteuses

Ephedrine + Tranylcypromine

Gravité: Contre-indiquée

Ephedrine and Tranylcypromine: contraindicated interaction.

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Résumé

Ephedrine releases norepinephrine indirectly and acts on adrenergic receptors, and MAO inhibition amplifies the response. Hypertensive crisis can occur.

Ce que signifie cette interaction, en termes simples

Ephedrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ephedrine belongs to Cardiovascular; Tranylcypromine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Indirect sympathomimetic release of norepinephrine potentiated by blocked MAO degradation of catecholamines.

Conduite à tenir

Avoid ephedrine and similar indirect sympathomimetics, including cold remedies, during and for 14 days after MAOI therapy. If hypotension needs treatment, prefer a direct-acting agent in small, titrated doses with blood pressure monitoring.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ephedrine with Tranylcypromine?

MediHelp rates the interaction as contraindicated. Ephedrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ephedrine releases norepinephrine indirectly and acts on adrenergic receptors, and MAO inhibition amplifies the response. Hypertensive crisis can occur.

How serious is the interaction between Ephedrine and Tranylcypromine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ephedrine and similar indirect sympathomimetics, including cold remedies, during and for 14 days after MAOI therapy. If hypotension needs treatment, prefer a direct-acting agent in small, titrated doses with blood pressure monitoring.

What other medicines interact with Tranylcypromine?

MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.

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