Référentiel des médicaments
Ephedrine
Ephedrine is a medicine in the class cardiovascular. It is used for hypotension.
- Classe médicamenteuse: Cardiovascular
- Indications: hypotension
Dernière mise à jour Sources: US FDA label
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L'essentiel
- Classe médicamenteuse
- Cardiovascular
- Formes courantes
- comprimé, injection
- Dosages courants
- 5 mg/ml, 12.5 mg, 25 mg
- Interactions connues
- 170 (Contre-indiquée: 6 · Majeure: 6 · Modérée: 88 · Mineure: 70)
- Noms commerciaux
- 5
- Pays et marchés
- 2
Indications
Mécanisme d'action
Sympathomimetic amine that directly agonizes alpha- and beta-adrenergic receptors and indirectly causes norepinephrine release from sympathetic neurons, raising arterial pressure, cardiac output and peripheral resistance.
Posologie adulte habituelle (résumé de la notice)
Clinically important hypotension in the setting of anesthesia: initial 5 mg to 10 mg IV bolus; additional boluses as needed; titrate to blood pressure goal; total not to exceed 50 mg
Grossesse et allaitement
- Grossesse
- Unknown Available human data have not identified a drug-associated risk of major birth defects, miscarriage or adverse outcomes; neonatal metabolic acidosis reported with maternal exposure, so monitor newborn. Animal decreased fetal survival and weight occurred with maternal toxicity.
- Allaitement
- Unknown Ephedrine is present in human milk in a single case report; effects on infant and milk production unknown. Weigh breastfeeding benefits against maternal need.
Effets indésirables signalés
- Nausea
- Vomiting
- Tachycardia
- Palpitations
- Reactive hypertension
- Bradycardia
Contre-indications
- None
Précautions particulières
- Serious postpartum hypertension, some with stroke, reported with vasopressor plus oxytocic; monitor blood pressure carefully.
- Repeated administration can cause tachyphylaxis; have an alternative pressor ready.
- Prophylactic use to prevent hypotension is associated with increased incidence of hypertension compared with treatment of hypotension.
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (170)
- Ephedrine + Isocarboxazid Contraindicated
- Ephedrine + Phenelzine Contraindicated
- Ephedrine + Procarbazine Contraindicated
- Ephedrine + Rasagiline Contraindicated
- Ephedrine + Selegiline Contraindicated
- Ephedrine + Tranylcypromine Contraindicated
- Caffeine + Ephedrine Major
- Ephedrine + Ergotamine Major
- Ephedrine + Linezolid Major
- Ephedrine + Maprotiline Major
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- Dosing by age, kidney and liver function, and further dose lines
- Renal and hepatic dose adjustments
- Dosing in older adults
- How to give it
- Pharmacokinetics
- IV preparation and dilution
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Questions fréquentes
What is Ephedrine used for?
Ephedrine is a medicine in the class cardiovascular. It is used for Hypotension.
What side effects have been reported with Ephedrine?
Nausea, Vomiting, Tachycardia, Palpitations, Reactive hypertension, Bradycardia.
Can Ephedrine be taken in pregnancy or while breastfeeding?
Pregnancy: Unknown. Available human data have not identified a drug-associated risk of major birth defects, miscarriage or adverse outcomes; neonatal metabolic acidosis reported with maternal exposure, so monitor newborn. Animal decreased fetal survival and weight occurred with maternal toxicity. Breastfeeding: Unknown. Ephedrine is present in human milk in a single case report; effects on infant and milk production unknown. Weigh breastfeeding benefits against maternal need.
What does Ephedrine interact with?
MediHelp lists 170 known interactions for Ephedrine. Contraindicated: 6 · Major: 6 · Moderate: 88 · Minor: 70. The most serious include Isocarboxazid, Phenelzine, Procarbazine.
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