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Interactions médicamenteuses

Epirubicin + Tofacitinib

Gravité: Majeure

Epirubicin and Tofacitinib: major interaction.

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Résumé

Epirubicin causes myelosuppression and immune compromise, and tofacitinib adds further immunosuppression. The combination raises the risk of serious and opportunistic infections and of severe neutropenia.

Ce que signifie cette interaction, en termes simples

Epirubicin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Epirubicin belongs to Oncology; Tofacitinib belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic immunosuppression and bone marrow suppression.

Conduite à tenir

Avoid concurrent use where possible and hold tofacitinib during myelosuppressive chemotherapy. Monitor neutrophil and lymphocyte counts and infection signs if combined.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Epirubicin with Tofacitinib?

MediHelp rates the interaction as major. Epirubicin and Tofacitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Epirubicin causes myelosuppression and immune compromise, and tofacitinib adds further immunosuppression. The combination raises the risk of serious and opportunistic infections and of severe neutropenia.

How serious is the interaction between Epirubicin and Tofacitinib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and hold tofacitinib during myelosuppressive chemotherapy. Monitor neutrophil and lymphocyte counts and infection signs if combined.

What other medicines interact with Tofacitinib?

MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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