Référentiel des médicaments
Epirubicin
Epirubicin is a medicine in the class oncology. It is used for breast cancer.
- Classe médicamenteuse: Oncology
- Indications: breast cancer
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Oncology
- Formes courantes
- injection, perfusion
- Dosages courants
- 10 mg/5 ml, 50 mg/25 ml, 50 mg
- Interactions connues
- 23 (Contre-indiquée: 1 · Majeure: 11 · Modérée: 9 · Mineure: 2)
- Noms commerciaux
- 26
- Pays et marchés
- 4
Indications
Mécanisme d'action
Anthracycline; intercalates between DNA base pairs and triggers cleavage by topoisomerase II, which results in cytocidal activity. Inhibits DNA helicase and generates cytotoxic free radicals.
Posologie adulte habituelle (résumé de la notice)
Adjuvant Breast Cancer Treatment: Day 1: Epirubicin 100 mg/m² IV, AND 5-fluorouracil 500 mg/m² IV, AND cyclophosphamide 500 mg/m² IV
Grossesse et allaitement
- Grossesse
- Unsafe Can cause fetal harm; avoid in the 1st trimester. Fetal and newborn heart toxicity has been reported after exposure. Any later use for cancer needs specialist care. Women: effective contraception during and for 6 months after the last dose.
- Allaitement
- Unsafe No human milk data; present in rat milk. Do not breastfeed during treatment and for at least 7 days after the last dose (LactMed: at least 8 days, based on half-life).
Effets indésirables signalés
- Vomiting
- Nausea
- Leukopenia
- Anemia
- Neutropenia
- Alopecia
Précautions particulières
- Administration of live or live-attenuated vaccines in patients immunocompromised by chemotherapeutic agents may result in serious or fatal infections
- Administration after previous radiation therapy may induce an inflammatory recall reaction at site of irradiation
- Therapy can cause fetal harm; advise patients of potential risk to a fetus and to use effective contraception
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (23)
- Adenovirus types 4 and 7 live + Epirubicin Contraindicated
- Belatacept + Epirubicin Major
- Cimetidine + Epirubicin Major
- Deferiprone + Epirubicin Major
- Dengue vaccine + Epirubicin Major
- Epirubicin + Etrasimod Major
- Epirubicin + Fingolimod Major
- Epirubicin + Ropeginterferon alfa 2b Major
- Epirubicin + Siponimod Major
- Epirubicin + Tofacitinib Major
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
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Questions fréquentes
What is Epirubicin used for?
Epirubicin is a medicine in the class oncology. It is used for Breast cancer.
What side effects have been reported with Epirubicin?
Vomiting, Nausea, Leukopenia, Anemia, Neutropenia, Alopecia.
Can Epirubicin be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. Can cause fetal harm; avoid in the 1st trimester. Fetal and newborn heart toxicity has been reported after exposure. Any later use for cancer needs specialist care. Women: effective contraception during and for 6 months after the last dose. Breastfeeding: Unsafe. No human milk data; present in rat milk. Do not breastfeed during treatment and for at least 7 days after the last dose (LactMed: at least 8 days, based on half-life).
What does Epirubicin interact with?
MediHelp lists 23 known interactions for Epirubicin. Contraindicated: 1 · Major: 11 · Moderate: 9 · Minor: 2. The most serious include Adenovirus types 4 and 7 live, Belatacept, Cimetidine.
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