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Interactions médicamenteuses

Ergotamine + Idelalisib

Gravité: Contre-indiquée

Ergotamine and Idelalisib: contraindicated interaction.

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Résumé

Idelalisib is a strong CYP3A inhibitor and is expected to substantially increase ergotamine exposure, risking severe vasospasm and ischemia. Strong CYP3A inhibitors are contraindicated with ergotamine.

Ce que signifie cette interaction, en termes simples

Ergotamine and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ergotamine belongs to Central Nervous System; Idelalisib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Idelalisib strongly inhibits CYP3A4, markedly reducing ergotamine clearance.

Conduite à tenir

Do not co-administer; use a non-ergot migraine therapy during idelalisib treatment.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ergotamine with Idelalisib?

MediHelp rates the interaction as contraindicated. Ergotamine and Idelalisib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Idelalisib is a strong CYP3A inhibitor and is expected to substantially increase ergotamine exposure, risking severe vasospasm and ischemia. Strong CYP3A inhibitors are contraindicated with ergotamine.

How serious is the interaction between Ergotamine and Idelalisib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use a non-ergot migraine therapy during idelalisib treatment.

What other medicines interact with Ergotamine?

MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.

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