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Interactions médicamenteuses

Erlotinib + Fosphenytoin

Gravité: Majeure

Erlotinib and Fosphenytoin: major interaction.

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Résumé

Fosphenytoin is converted to phenytoin, a strong CYP3A4 inducer, and may markedly lower erlotinib exposure. This can compromise cancer treatment.

Ce que signifie cette interaction, en termes simples

Erlotinib and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Erlotinib belongs to Oncology; Fosphenytoin belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Phenytoin induces CYP3A4 and possibly P-glycoprotein, increasing erlotinib clearance.

Conduite à tenir

Use a non-inducing anticonvulsant where possible. If unavoidable, monitor response and consider increasing erlotinib dose as per labeling, with dose reduction after the inducer is stopped.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Erlotinib with Fosphenytoin?

MediHelp rates the interaction as major. Erlotinib and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosphenytoin is converted to phenytoin, a strong CYP3A4 inducer, and may markedly lower erlotinib exposure. This can compromise cancer treatment.

How serious is the interaction between Erlotinib and Fosphenytoin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing anticonvulsant where possible. If unavoidable, monitor response and consider increasing erlotinib dose as per labeling, with dose reduction after the inducer is stopped.

What other medicines interact with Erlotinib?

MediHelp also lists interactions of Erlotinib with, for example, Amobarbital, Apalutamide, Carbamazepine. The full list is on the Erlotinib page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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