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Interactions médicamenteuses

Fosphenytoin + Lurasidone

Gravité: Contre-indiquée

Fosphenytoin and Lurasidone: contraindicated interaction.

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Résumé

Fosphenytoin is converted to phenytoin, a strong CYP3A4 inducer that can reduce lurasidone exposure dramatically. This may lead to loss of antipsychotic efficacy and relapse. Strong inducers are contraindicated with lurasidone.

Ce que signifie cette interaction, en termes simples

Fosphenytoin and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fosphenytoin belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Induction of CYP3A4 by phenytoin increases lurasidone clearance.

Conduite à tenir

Avoid the combination; use an alternative anticonvulsant or an antipsychotic not dependent on CYP3A4, and monitor psychiatric status.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fosphenytoin with Lurasidone?

MediHelp rates the interaction as contraindicated. Fosphenytoin and Lurasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosphenytoin is converted to phenytoin, a strong CYP3A4 inducer that can reduce lurasidone exposure dramatically. This may lead to loss of antipsychotic efficacy and relapse. Strong inducers are contraindicated with lurasidone.

How serious is the interaction between Fosphenytoin and Lurasidone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative anticonvulsant or an antipsychotic not dependent on CYP3A4, and monitor psychiatric status.

What other medicines interact with Lurasidone?

MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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