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Interactions médicamenteuses

Fosphenytoin + Ranolazine

Gravité: Contre-indiquée

Fosphenytoin and Ranolazine: contraindicated interaction.

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Résumé

Phenytoin, formed from fosphenytoin, is a strong CYP3A4 inducer and can substantially lower ranolazine levels, causing loss of antianginal effect. Ranolazine labeling contraindicates CYP3A inducers.

Ce que signifie cette interaction, en termes simples

Fosphenytoin and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fosphenytoin belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Induction of CYP3A4 (and P-gp) increases ranolazine clearance.

Conduite à tenir

Avoid the combination and choose another antianginal. Use a different anticonvulsant if the patient needs ranolazine.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fosphenytoin with Ranolazine?

MediHelp rates the interaction as contraindicated. Fosphenytoin and Ranolazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenytoin, formed from fosphenytoin, is a strong CYP3A4 inducer and can substantially lower ranolazine levels, causing loss of antianginal effect. Ranolazine labeling contraindicates CYP3A inducers.

How serious is the interaction between Fosphenytoin and Ranolazine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antianginal. Use a different anticonvulsant if the patient needs ranolazine.

What other medicines interact with Ranolazine?

MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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