Interactions médicamenteuses
Estradiol + Ospemifene
Gravité: Contre-indiquée
Estradiol and Ospemifene: contraindicated interaction.
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Résumé
Ospemifene is an estrogen agonist/antagonist and should not be given with estrogens. Combined use adds to the risk of endometrial and thromboembolic effects and has not been shown to be safe.
Ce que signifie cette interaction, en termes simples
Estradiol and Ospemifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Estradiol belongs to Endocrine; Ospemifene belongs to Endocrine.
Pourquoi elle survient
Additive estrogenic receptor activity with overlapping risks of endometrial stimulation and venous thromboembolism.
Conduite à tenir
Do not combine; use either ospemifene or estrogen therapy for dyspareunia.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Estradiol
- Anastrozole + Estradiol Contre-indiquée
- Estradiol + Fezolinetant Contre-indiquée
- Antithrombin alfa + Estradiol Majeure
- Antithrombin iii + Estradiol Majeure
- Estradiol + Exemestane Majeure
- Estradiol + Fosphenytoin Majeure
Autres interactions de Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contre-indiquée
- Clomiphene + Ospemifene Majeure
- Fluconazole + Ospemifene Majeure
- Ketoconazole + Ospemifene Majeure
- Ospemifene + Raloxifene Majeure
- Ospemifene + Rifampicin Majeure
Questions fréquentes
Can I take Estradiol with Ospemifene?
MediHelp rates the interaction as contraindicated. Estradiol and Ospemifene are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ospemifene is an estrogen agonist/antagonist and should not be given with estrogens. Combined use adds to the risk of endometrial and thromboembolic effects and has not been shown to be safe.
How serious is the interaction between Estradiol and Ospemifene?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; use either ospemifene or estrogen therapy for dyspareunia.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Antithrombin alfa. The full list is on the Estradiol page.
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