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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Ospemifene + Rifampicin

Gravité: Majeure

Ospemifene and Rifampicin: major interaction.

Dernière mise à jour

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Résumé

Rifampicin considerably lowers ospemifene exposure, which may reduce its effect on dyspareunia and vaginal dryness.

Ce que signifie cette interaction, en termes simples

Ospemifene and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Ospemifene belongs to Endocrine; Rifampicin belongs to Anti Bacterial.

Niveau de preuve: High

Pourquoi elle survient

Induction of CYP3A4, CYP2C9 and CYP2C19 by rifampicin increases ospemifene clearance.

Conduite à tenir

Do not use together; choose an alternative therapy if rifampicin is required.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ospemifene with Rifampicin?

MediHelp rates the interaction as major. Ospemifene and Rifampicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin considerably lowers ospemifene exposure, which may reduce its effect on dyspareunia and vaginal dryness.

How serious is the interaction between Ospemifene and Rifampicin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; choose an alternative therapy if rifampicin is required.

What other medicines interact with Ospemifene?

MediHelp also lists interactions of Ospemifene with, for example, Bazedoxifene-conjugated estrogens, Estradiol, Clomiphene. The full list is on the Ospemifene page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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